GSK is a global biopharma company focused on uniting science, technology, and talent to improve health outcomes. The Summer Co-op position in the DMPK Modeling group offers an opportunity to develop advanced PBPK modeling skills, specifically for Antibody-Drug Conjugates (ADCs), while collaborating with cross-functional teams.
Comprehensive characterization of ADC payload ADME using both internal and published data
Independent development and validation of PBPK model for ADC payloads in Simcyp, often utilizing Trastuzumab-based ADCs as an exemplar system to explore mAb PK, linker stability, and payload exposure
Integration of mechanistic data or QSAR-predicted parameters to ensure broad applicability of models, identifying key data gaps and informing future ADC design strategies
Collaboration across various cross-functional teams (toxicology, biology, chemistry, clinical pharmacology, formulations) to apply model-informed drug development strategies for ADCs
Work towards building a template PBPK model in Simcyp for multiple ADC payload chemotypes, integrating mechanistic sub-models or QSAR-based predictions
Present modeling outputs in internal team and department meetings
The goal is to be able to generate a high-impact publication detailing the generic ADC payload PBPK model and its applications
Qualification
Required
Pursuing a Master's or PhD in a relevant scientific discipline (Pharmacokinetics, Pharmacology, Biochemistry or other DMPK related sciences)
Must be able to work full-time (35-40 hours/week) throughout the duration of the 3 to 6-month Co-op (August/September ~ December 2026)
Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program. Post-doctoral candidates are not eligible
Experience with application of PBPK software SimCYP
Basic knowledge of DMPK processes in drug discovery and development
Basic understanding of the in vitro/in vivo experiments used to describe general ADME principles especially drug absorption and drug distribution
Scientific writing and presentation ability with excellent verbal communication skills
Must successfully pass a drug screen and background check prior to assignment target start date
Once your application is submitted, you will be prompted to complete our immersive GSK Digital Assessment. A passing score is required to proceed in the application process
Preferred
Benefits
GSK Interns and Co-ops are offered a competitive hourly pay rate and benefits.
Benefits eligibility determined the month following date of hire
Eligible for relocation stipend (one-time payment to help offset housing & relocation expenses) if hired for an on-site role or hybrid role and reside outside of 50-miles from their assigned work location
This role will be eligible for overtime pay, in accordance with federal and state requirement
GSK manufactures pharmaceutical medicines, vaccines, and consumer healthcare products.
